A simple, accurate, validated, economic and reproducible method for the estimation of Griseofulvin in bulk and pharmaceutical dosage forms has been developed. Methanol was chosen as the solvent system. The λmax was found to be 293nm. The responses were linear in the range of 5-35µg/ml. The regression equation of the calibration graph and correlation coefficient were found to be y = 0.078x - 0.001 and 0.999 respectively. The %RSD values for both intraday and interday precision were less than 1%. The recovery of the drug from the sample was ranged between 99.62% and 100.49%. The proposed method was validated for precision, accuracy, intraday and interday assay. Commercial tablets containing 375mg and 250mg of Griseofulvin were analyzed by the proposed method and the results were well within the claimed limits. Further stability studies of Griseofulvin were carried out under acidic, alkaline, hydrolytic and photolytic conditions as per SIAM (Stability Indicating Assay Methods) as described by ICH.
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